2
Why does the liver enlarge in thalassemia?
- 1 people answered
3 Votes
1 Contributor
2096 Views 
0 Saved
3 Votes 1 Contributor2096 Views 0 SavedYou might also be interested in
Dr Thomas Starzl was the first surgeon who transplanted liver. He died at the age of 90years. The first attempt was performed in 1963 but the patient died due to uncontrolled bleeding. Until 1967 multiple unsuccessful attempts were made by various surgeons. In 1967 Dr Thomas transplanted liver of ni....
Miconazole is considered as one the antifungal agent:- Miconazole is used in the treatment of skin infections such as athlete's foot, jock itch, ringworm, and other fungal skin infections like candidacies. This type of medication is also used to treat a skin condition known as pityriasis which is a....
Deficiency of essential fatty acids results in a fatty liver because essential fatty acids are important for a number of biochemical processes, including prostaglandin, thromboxane, lipoxin, & leukotriene pathways. These pathways are critical to the normal functioning of multiple organ systems, ....
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.